Research into extending the lifespan of dogs and cats

Here are some alarming facts.

Over the past few decades, the number of dogs and cats being diagnosed with cancer has become alarmingly high. The awareness and the knowledge of this may partially be attributed to the internet for making such information more transparent and available.  

Facts:

1. 50% of all disease related deaths are caused by cancer. ¹
   
2. Cancer is the number one cause of death in older pets. ²
3. Dogs and humans get cancer at about the same rate. ³
4. Like humans dogs can develop cancer in virtually any part of their bodies. ⁴

Are we closer to a cure?

After studying cancer in pets for nearly 15 years, I have noticed that conventional cancer prevention and the standard of care treatments have not improved much over the last 50 years. I won't get into much detail but considering the time and money spent on research, you would have hoped for better results by now. Yes, they have managed to prolong the time patients/dogs survive short-term in some types of cancer.  1-3 years after treatments but looking longer term (3-5 years) not much of an improvement has been made. The billions of dollars spent on research are for the most focused on treatments of cancer, not the cause. We need to find the cause! Sadly, pets often die from the side effects of the standard of care as frequently as cancer itself. The cause of cancer and prevention is not receiving enough attention to make a difference. Pets are getting cancer more now than ever before, close to 50% of dogs are battling this awful disease.

 My vet told me "Your dog has cancer"

I lost Camelot I to cancer when he was 8 1/2 

I lost Camelot I to cancer when he was 8 ½ and I never want to hear those words again! Having a dog succumb to cancer was a heartbreaking experience. I am determined that no other dog in my care will ever be diagnosed with cancer. The recommendations I provide on this site are based on my research and experience over the past 15 years. I am not a medical professional and I am only sharing knowledge I have gained by observing what works over and over again

Can you reduce the risk of your pet getting cancer?

 I believe so, and I'm on a mission to prove it!

After going through the horrible experience of having a pet die from cancer, I have dedicated over the last 16 years hundreds and hundreds of hours researching how I can reduce the risk of cancer in pets. I have tested over 50 natural products and many strategies. There is not a particular program that can protect your pet 100% from ever getting cancer, but what I describe below comes darn close. 

I'm not a medical professional. I base my knowledge and my experience gathered from researching cancer in dogs over the last 16 years. I have tried everything I outline here on my pets. Over the years, the risks have yielded only rewards. I know I'm on to something amazing when it comes to preventing cancer in pets. I just need time to prove that it works. Meanwhile, I'm offering you my approach to prevention so you can implement this to protect your pets. It's an entirely natural approach, and it won't hurt your pet. There are no guarantees, and I know you understand that. 

Resvantage® - Resveratrol 

For the last 16 years, I have researched over a dozen natural products that claim to prevent and treat cancer. 

Many know that I'm a believer in another product made from fruit seeds. When used with my protocol, I have seen it lead to amazing results.

Since October 2015, I have focused on and tested resveratrol, another natural product with very promising applications. I have known about resveratrol for several years now, including its many reported benefits. However, issues related to poor bioavailability and sensitivity to oxygen kept me from taking a closer look at it. I do not recommend products I do not trust, and I have always been very careful about this. I must know the source, the manufacturing process (if any) and the level of bioavailability of the product. That is why, out of the dozens of products I have looked into, I only recommend a fraction of them. 

My view on resveratrol changed after discovering a product called Resvantage®. They utilize a unique technology to prevent oxidation and ensure maximum potency, all by using a patented process by Capsugal® called Lipcaps®. The resveratrol is encapsulated in an oxygen-free, nitrogen-rich environment. It is lab-tested during all phases of the process, ensuring that the active compounds are free of heavy metal toxicity and microbiological contaminants. 

Resvantage® is also micronized, which greatly increases its bioavailability, since more of the resveratrol penetrates the blood barrier and ends up in the cells. 

In short, Resvantage® may be my new favorite product, and I feel it is time for me to recommend it. I have teamed up with a great company that has made it for dogs, cats and horses. I have engaged in hours of great conversation with the owner and developer, and I'm completely confident that his resveratrol product is the very best and the safest on the market today. That is a strong statement coming from me. 

The company also understands my approach, and they see how ketosis is an excellent first 'punch' to the cancer cells, making them weak and vulnerable to cancer-fighting supplements, which in turn promotes apoptosis (the death of cancer cells). In this weakened state, resveratrol may even be more efficient as part of a cancer prevention and treatment protocol. From my experience, I see this as a very promising natural approach to managing cancer. 

Be aware that there are impure resveratrol products on the market made from secondary sources. These are inferior when it comes to both potency and bioavailability (the process of reaching the cells), and it took me some time to sort them out and find the right one. Oxygen is resveratrol’s biggest enemy, rendering it worthless very quickly if not kept in an oxygen-free environment. 

You may have heard of resveratrol before. It is found in many plants, including grape skin, raspberries, pomegranate, blueberries, pine, raw cacao and giant knotweed.  

Resvantage®'s source of resveratrol is the giant knotweed. This is the same source as the pharmaceutical-grade resveratrol used in studies by medical research institutions and universities, including NIH. 

In preclinical trials, of which there are over 600 so far in 2016, resveratrol has been shown to possess copious biological functions that could potentially be applied to the prevention and treatment of cancer, cardiovascular and neurodegenerative diseases. The results from these trials are beyond promising. This is the best I have seen from natural products – and with little to no side effects.

Other Possible Health Benefits

Resveratrol has also shown to have other health benefits, including antioxidant, anti-inflammatory, cardio-protective and neuroprotective properties. It helps support normal metabolic functions and has been shown in studies to counter insulin factors. 

Studies show that resveratrol increases the expression of the enzyme SIRT1, which boosts insulin sensitivity and improves mitochondrial function. Combined, these pharmacological effects provide a new and effective way of managing type II diabetes. Resvantage® Canine and Resvantage® Feline are being used clinically to manage diabetes and glycemic seizures. 

Resvantage® is also used to help maintain normal brain function in elderly pets. 

Resveratrol Studies Related to Possible Cancer Prevention

Some compounds only become carcinogenic after they have been metabolized by phase I biotransformation enzymes such as cytochrome P450 enzymes (1,2). Resveratrol has shown to inhibit the expression of certain P450 enzymes, thereby limiting the activation of procarcinogens. This could potentially prevent cancer. 

As a result of damage to the DNA, the cell cycle can be interrupted and disrupt pathways leading to apoptosis (cell death). This damage to the regulation of the cell cycle can result in unregulated cell mutations that contribute to the development of cancer. In other words, cancer cells ignore the signals that would initiate apoptosis in damaged 'healthy' cells. Studies show that this loss of cell cycle arrest can be reinduced by resveratrol in a number of cancer cell lines (3). 

Resveratrol has been found to inhibit the invasion of cancerous cells in normal tissue by using matrix metalloproteinases enzymes (4.5). 

One essential requirement for rapid cancer cell proliferation is the ability to develop new blood vessels through a process known as angiogenesis. This process, which is vital to cancer cells, has shown to be interrupted by resveratrol in vitro (6,7) and in vivo (8).

Inflammation promotes angiogenesis and cellular proliferation, and it inhibits apoptosis. Inflammatory enzymes, including cyclooxygenases and lipoxygenases, have shown to be inhibited by resveratrol (9, 10).

There is a strong indication that resveratrol inhibits pro-inflammatory transcription factors like NFkB and AP-1 (11, 12).

My Conclusion.

I believe that this product has many applications, some of which have yet to be discovered. I'm excited about this, and I'm giving it to all my pets as a part of my prevention protocol (link). 

I have created a category for those who use this product in their own prevention protocol. If you would like to be added to the list, please take part in this study by letting me know. That way I can add your pet to the group. 

I highly recommend that you try this. It is a bit expensive, but the cost is negligible compared to other medications, drugs and therapies such as chemo or radiation. If Resvantage® is an alternative to chemo, you will save 10k and avoid poisoning your pet.  

I highly recommend that you try this. It is a bit expensive, but the cost is negligible compared to other medications, drugs and therapies such as chemo or radiation. If Resvantage® is an alternative to chemo, you will save 10k and avoid poisoning your pet. 

You should see a difference in just a few days. If your dog is old and suffers from any joint issues, you will also see a noticeable difference in his or her mobility in just a few days. 

Suggested use: 

Dogs: 1 capsule for every 30lbs

Cats: 1 capsule daily

If you are giving your pet multiple capsules per day, avoid administering the capsules in a short period of time. For example, for a 60lb dog, administer one capsule in the morning and one in the afternoon or evening.

NOTE: : If you use Resvantage® to treat severe conditions, please contact me for advice on dosage. (Use the blue tab you see on the right side of this page.)

References:

1.  Chen ZH, Hurh YJ, Na HK, et al. Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Carcinogenesis. 2004;25(10):2005-2013.  (PubMed)

2.  Ciolino HP, Yeh GC. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol Pharmacol. 1999;56(4):760-767.  (PubMed) 

3.  Tome-Carneiro J, Larrosa M, Gonzalez-Sarrias A, Tomas-Barberan FA, Garcia-Conesa MT, Espin JC. Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des. 2013;19(34):6064-6093.  (PubMed)

4.  Yu H, Pan C, Zhao S, Wang Z, Zhang H, Wu W. Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Biomed Pharmacother. 2008;62(6):366-372.  (PubMed)

5.  Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001;171(1):11-16.  (PubMed) 

6.  Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001;171(1):11-16.  (PubMed) 

7.  Lin MT, Yen ML, Lin CY, Kuo ML. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation. Mol Pharmacol. 2003;64(5):1029-1036.  (PubMed) 

8.  Chen Y, Tseng SH. Review. Pro- and anti-angiogenesis effects of resveratrol. In Vivo. 2007;21(2):365-370.  (PubMed) 

9.  Donnelly LE, Newton R, Kennedy GE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. 2004;287(4):L774-783.  (PubMed) 

10.  Pinto MC, Garcia-Barrado JA, Macias P. Resveratrol is a potent inhibitor of the dioxygenase activity of lipoxygenase. J Agric Food Chem. 1999;47(12):4842-4846.  (PubMed) 

11.  Shankar S, Singh G, Srivastava RK. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front Biosci. 2007;12:4839-4854.  (PubMed) 

12.  de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005;49(5):405-430.  (PubMed)